Seroepidemiological Study on SARS-CoV IgG Antibodies of Different Populations from Several Areas
Identifieur interne : 004641 ( Main/Exploration ); précédent : 004640; suivant : 004642Seroepidemiological Study on SARS-CoV IgG Antibodies of Different Populations from Several Areas
Auteurs : Yu-Ling Shi ; Lin-Hai Li ; Xin-Wei Chu ; Qing Chen ; Yun-Long Wang ; Qing-Jun Ma ; Cheng Cao ; Shou-Yi YuSource :
- International Journal of Biomedical Science : IJBS [ 1550-9702 ] ; 2005.
Abstract
In order to investigate the clinical and epidemiological rules of severe acute respiratory syndrome (SARS), rates and levels SARS coronavirus (SARS-CoV) IgG antibodies of the patients and community populations from several areas were detected.
Indirect immunofluorescent assay (IFA) and double-antigen sandwich enzyme-linked immunosorbent assay (ELISA) were used to detect the SARS coronavirus-specific IgG antibodies in sera of 1700, including 1453 general populations from Hongkong, Marco, Guangzhou and Peking and 257 SARS patients from Guangzhou and Peking. The dynamics of the serum antibodies of SARS patients were observed from 3 to 360 days after onset of symptoms.
90% of 257 patient serum specimens after 20 days of disease onset showed positive SARS-CoV IgG either using ELISA or IFA. 257 SARS patients, antibodies titers increased steadily in early 4 to 6 months after onset of SARS. The titers of most cases came to the peak in the 6th month. then antibodies titers declined rapidly in some cases. However, all specimens still were positive for SARS-CoV IgG in the 48th month.
This study suggest that few inapparent infectious patients exist during SARS epidemic. Serum IgG antibodies has diagnostic value for SARS in the late course of disease and the antibodies present more than 48 months.
Url:
PubMed: 23674957
PubMed Central: 3614584
Affiliations:
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China;</italic></nlm:aff></affiliation></author><author><name sortKey="Chen, Qing" sort="Chen, Qing" uniqKey="Chen Q" first="Qing" last="Chen">Qing Chen</name><affiliation><nlm:aff id="aff2"><italic>Department of Epidemiology, First Military Medical University, Guangzhou, China;</italic></nlm:aff></affiliation></author><author><name sortKey="Wang, Yun Long" sort="Wang, Yun Long" uniqKey="Wang Y" first="Yun-Long" last="Wang">Yun-Long Wang</name><affiliation><nlm:aff id="aff3"><italic>Center of Biotechnology and Engineering of Henan Province, Zhengzhou, China;</italic></nlm:aff></affiliation></author><author><name sortKey="Ma, Qing Jun" sort="Ma, Qing Jun" uniqKey="Ma Q" first="Qing-Jun" last="Ma">Qing-Jun Ma</name><affiliation><nlm:aff id="aff4"><italic>Institute Biotechnology, Academy of Military Medical Sciences, Beijing, China</italic></nlm:aff></affiliation></author><author><name sortKey="Cao, Cheng" sort="Cao, Cheng" uniqKey="Cao C" first="Cheng" last="Cao">Cheng 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China;</italic></nlm:aff></affiliation></author><author><name sortKey="Li, Lin Hai" sort="Li, Lin Hai" uniqKey="Li L" first="Lin-Hai" last="Li">Lin-Hai Li</name><affiliation><nlm:aff id="aff1"><italic>Clinical Laboratory, Guangzhou General Hospital of PLA, Guangzhou, China;</italic></nlm:aff></affiliation></author><author><name sortKey="Chu, Xin Wei" sort="Chu, Xin Wei" uniqKey="Chu X" first="Xin-Wei" last="Chu">Xin-Wei Chu</name><affiliation><nlm:aff id="aff2"><italic>Department of Epidemiology, First Military Medical University, Guangzhou, China;</italic></nlm:aff></affiliation></author><author><name sortKey="Chen, Qing" sort="Chen, Qing" uniqKey="Chen Q" first="Qing" last="Chen">Qing Chen</name><affiliation><nlm:aff id="aff2"><italic>Department of Epidemiology, First Military Medical University, Guangzhou, China;</italic></nlm:aff></affiliation></author><author><name sortKey="Wang, Yun Long" sort="Wang, Yun Long" uniqKey="Wang Y" first="Yun-Long" last="Wang">Yun-Long Wang</name><affiliation><nlm:aff id="aff3"><italic>Center of Biotechnology and Engineering of Henan Province, Zhengzhou, China;</italic></nlm:aff></affiliation></author><author><name sortKey="Ma, Qing Jun" sort="Ma, Qing Jun" uniqKey="Ma Q" first="Qing-Jun" last="Ma">Qing-Jun Ma</name><affiliation><nlm:aff id="aff4"><italic>Institute Biotechnology, Academy of Military Medical Sciences, Beijing, China</italic></nlm:aff></affiliation></author><author><name sortKey="Cao, Cheng" sort="Cao, Cheng" uniqKey="Cao C" first="Cheng" last="Cao">Cheng Cao</name><affiliation><nlm:aff id="aff4"><italic>Institute Biotechnology, Academy of Military Medical Sciences, Beijing, China</italic></nlm:aff></affiliation></author><author><name sortKey="Yu, Shou Yi" sort="Yu, Shou Yi" uniqKey="Yu S" first="Shou-Yi" last="Yu">Shou-Yi Yu</name><affiliation><nlm:aff id="aff2"><italic>Department of Epidemiology, First Military Medical University, Guangzhou, China;</italic></nlm:aff></affiliation></author></analytic><series><title level="j">International Journal of Biomedical Science : IJBS</title><idno type="ISSN">1550-9702</idno><idno type="eISSN">1555-2810</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Objective:</title><p>In order to investigate the clinical and epidemiological rules of severe acute respiratory syndrome (SARS), rates and levels SARS coronavirus (SARS-CoV) IgG antibodies of the patients and community populations from several areas were detected.</p></sec><sec><title>Methods:</title><p>Indirect immunofluorescent assay (IFA) and double-antigen sandwich enzyme-linked immunosorbent assay (ELISA) were used to detect the SARS coronavirus-specific IgG antibodies in sera of 1700, including 1453 general populations from Hongkong, Marco, Guangzhou and Peking and 257 SARS patients from Guangzhou and Peking. The dynamics of the serum antibodies of SARS patients were observed from 3 to 360 days after onset of symptoms.</p></sec><sec><title>Results:</title><p>90% of 257 patient serum specimens after 20 days of disease onset showed positive SARS-CoV IgG either using ELISA or IFA. 257 SARS patients, antibodies titers increased steadily in early 4 to 6 months after onset of SARS. The titers of most cases came to the peak in the 6th month. then antibodies titers declined rapidly in some cases. However, all specimens still were positive for SARS-CoV IgG in the 48th month.</p></sec><sec><title>Conclusions:</title><p>This study suggest that few inapparent infectious patients exist during SARS epidemic. Serum IgG antibodies has diagnostic value for SARS in the late course of disease and the antibodies present more than 48 months.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Thomas, G" uniqKey="Thomas G">G Thomas</name></author><author><name sortKey="Ksiazek, Dvm" uniqKey="Ksiazek D">DVM Ksiazek</name></author><author><name sortKey="Dean, Erdman" uniqKey="Dean E">Erdman Dean</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Si, Bing Yin" uniqKey="Si B">Bing-yin Si</name></author><author><name sortKey="Yang, Bai An" uniqKey="Yang B">Bai-an Yang</name></author><author><name sortKey="Yu, Man" uniqKey="Yu M">Man Yu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shi, Yl" uniqKey="Shi Y">YL Shi</name></author><author><name sortKey="Yi, Yp" uniqKey="Yi Y">YP Yi</name></author><author><name sortKey="Li, P" uniqKey="Li P">P Li</name></author><author><name sortKey="Kuang, Tj" uniqKey="Kuang T">TJ Kuang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wong, Gwk" uniqKey="Wong G">GWK Wong</name></author><author><name sortKey="Hui, Dsc" uniqKey="Hui D">DSC Hui</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shi, Yuling" uniqKey="Shi Y">Yuling Shi</name></author><author><name sortKey="Li, Linhai" uniqKey="Li L">Linhai Li</name></author><author><name sortKey="Wan, Zhuoyue" uniqKey="Wan Z">Zhuoyue Wan</name></author><author><name sortKey="Chu, Xinwei" uniqKey="Chu X">Xinwei Chu</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Cao, Cheng" sort="Cao, Cheng" uniqKey="Cao C" first="Cheng" last="Cao">Cheng Cao</name><name sortKey="Chen, Qing" sort="Chen, Qing" uniqKey="Chen Q" first="Qing" last="Chen">Qing Chen</name><name sortKey="Chu, Xin Wei" sort="Chu, Xin Wei" uniqKey="Chu X" first="Xin-Wei" last="Chu">Xin-Wei Chu</name><name sortKey="Li, Lin Hai" sort="Li, Lin Hai" uniqKey="Li L" first="Lin-Hai" last="Li">Lin-Hai Li</name><name sortKey="Ma, Qing Jun" sort="Ma, Qing Jun" uniqKey="Ma Q" first="Qing-Jun" last="Ma">Qing-Jun Ma</name><name sortKey="Shi, Yu Ling" sort="Shi, Yu Ling" uniqKey="Shi Y" first="Yu-Ling" last="Shi">Yu-Ling Shi</name><name sortKey="Wang, Yun Long" sort="Wang, Yun Long" uniqKey="Wang Y" first="Yun-Long" last="Wang">Yun-Long Wang</name><name sortKey="Yu, Shou Yi" sort="Yu, Shou Yi" uniqKey="Yu S" first="Shou-Yi" last="Yu">Shou-Yi Yu</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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